TOMMorrow's AD marker

Familiarity-based memory as an early cognitive marker of preclinical and prodromal AD.

There is great interest in the development of cognitive markers that differentiate "normal" age-associated cognitive change from that of Alzheimer's disease (AD) in its prodromal (i.e., mild cognitive impairment; MCI) or even preclinical stages. Dual process models posit that recognition memory is supported by the dissociable processes of recollection and familiarity. Familiarity-based memory h...

Is imaging of tau the preferable marker of cognitive impairment in AD? DEBATE

Department of Psychiatry, University of Geneva School of Medicine, 2, ch Petit Bel-Air, 1225 Geneva, Switzerland Early clinic-pathological studies demonstrated that the two cardinal lesions associated with Alzheimer disease (AD), neurofibrillary tangles (NFT) and amyloid deposits, have a differential impact on cognition both at early and late stages of the neurodegenerative process. In contrast...

Gray matter atrophy rate as a marker of disease progression in AD

Global gray matter (GM) atrophy rates were quantified from magnetic resonance imaging (MRI) over 6- and 12-month intervals in 37 patients with Alzheimer's disease (AD) and 19 controls using: (1) nonlinear registration and integration of Jacobian values, and (2) segmentation and subtraction of serial GM volumes. Sample sizes required to power treatment trials using global GM atrophy rate as an o...

KAI-1 ad p53 expression in Odontogenic cysts: An Immuno-his- tochemical Marker Study

Background: KAI-1/CD82 is a tumor suppressor gene with decreased gene expression being associated with increased invasive ability of Oral Squamous Cell Carcinoma (OSCC) and as hypothesised for various odontogenic cysts and tumors. p53 protein functions in G1-S phase of the cell cycle to allow the repair of damaged DNA. In the present study, p53 and KAI-1 expression was investigated by using mon...

Combining Attentional Control and Semantic Memory Retrieval: A Sensitive Marker for Early Stage AD and AD-related Biomarkers in Healthy Older Adults